Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0085 | 0.006 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0114 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0026 | 0.003 |
Plasmodium falciparum | kinesin-5 | 0.0083 | 0.121 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0114 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0114 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0026 | 0.003 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0114 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0026 | 0.003 |
Echinococcus multilocularis | kinesin family 1 | 0.0639 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0085 | 0.0502 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0114 | 0.0741 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0605 | 0.0696 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0085 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.046 | 0.3661 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0085 | 0.0502 |
Plasmodium vivax | kinesin-5 | 0.0083 | 0.121 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0545 | 0.4383 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0026 | 0.003 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0114 | 0.0741 |
Giardia lamblia | Kinesin-5 | 0.0083 | 0.121 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0545 | 0.052 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0545 | 0.052 |
Schistosoma mansoni | hypothetical protein | 0.0556 | 0.8688 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0083 | 0.121 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0083 | 0.121 | 0.1393 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0083 | 0.121 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0085 | 0.0098 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0085 | 0.0098 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0605 | 0.0696 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0114 | 0.0741 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0545 | 0.4383 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0503 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0085 | 0.006 |
Entamoeba histolytica | kinesin, putative | 0.0083 | 0.121 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0114 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0503 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0026 | 0.003 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0083 | 0.121 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0114 | 0.0741 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0085 | 0.006 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0114 | 0.0741 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0026 | 0.003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.