Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor 1 | 0.003 | 0.3615 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.003 | 0.3615 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.3615 | 0.3615 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0029 | 0.2583 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.004 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Chlamydia trachomatis | glutamine binding protein | 0.0029 | 0.2583 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.004 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0036 | 0.7417 | 0.7417 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0036 | 0.7417 | 0.7417 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.003 | 0.3615 | 0.3615 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0036 | 0.7417 | 0.7417 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0029 | 0.2583 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0029 | 0.2583 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0036 | 0.7417 | 0.7417 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.003 | 0.3615 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0036 | 0.7417 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0029 | 0.2583 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.003 | 0.3615 | 0.3615 |
Brugia malayi | Glutamate receptor 2 precursor | 0.003 | 0.3615 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0029 | 0.2583 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.7417 | 0.7417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | = 1.3 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | = 3.2 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | = 3.2 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (functional) | = 13.4 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (functional) | = 13.4 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (functional) | = 14.9 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (functional) | = 14.9 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (binding) | = 55.4 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | = 55.4 uM | Inhibition of [3H]-AMPA binding to AMPA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (functional) | = 58.7 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (functional) | = 58.7 uM | Inhibition of 40 uM AMPA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (binding) | = 98 uM | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | = 98 uM | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | Inhibition of 40 uM NMDA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of [3H]-CGS-19,755 binding to NMDA receptor of rat brain membranes. | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | Inhibition of 40 uM NMDA induced depolarizations in a rat cortical slice. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.