Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0207 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0516 | 0.0128 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.0925 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.1019 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0042 | 0.0516 | 0.0925 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0393 | 0.0397 |
Brugia malayi | Peptidase family M1 containing protein | 0.0042 | 0.0516 | 0.0541 |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.5066 | 0.5853 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0393 | 0.0397 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0516 | 0.0541 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0042 | 0.0516 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.8618 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0393 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0393 | 0.734 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.0925 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.0925 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0393 | 0.0679 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.0516 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 1 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0042 | 0.0516 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.0516 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.8618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.4399 | 0.5074 |
Onchocerca volvulus | 0.0143 | 0.5066 | 0.504 | |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.5066 | 1 |
Onchocerca volvulus | 0.0042 | 0.0516 | 0.0466 | |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0.0516 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0393 | 0.734 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0.0516 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.3836 | 0.4416 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0053 | 0.0104 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0516 | 0.0128 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.1019 |
Loa Loa (eye worm) | aminopeptidase N | 0.0042 | 0.0516 | 0.0541 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0.0516 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.0516 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.5066 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.1019 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0.0516 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0207 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.0516 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.1019 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0.0516 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0053 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.0925 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0393 | 0.0776 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.0516 | 0.0925 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0393 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3168 | 0.3637 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0.0516 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.66 uM | Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate addition by UV-Vis spectrophotometric analysis | ChEMBL. | 24900417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.