Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.2036 | 0.1017 | 0.2505 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4554 | 0.3955 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.244 | 0.1488 | 0.3708 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8542 | 0.8606 | 0.8602 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2114 | 0.1107 | 0.2736 |
Echinococcus multilocularis | protein kinase c iota type | 0.2036 | 0.1017 | 0.2505 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.244 | 0.1488 | 0.3708 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.1194 | 0.0035 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.2114 | 0.1107 | 0.1076 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.4554 | 0.3955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.244 | 0.1488 | 0.1459 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8542 | 0.8606 | 0.8602 |
Brugia malayi | Protein kinase c protein 2 | 0.339 | 0.2596 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.2114 | 0.1107 | 0.2736 |
Echinococcus granulosus | protein kinase C gamma type | 0.3713 | 0.2973 | 0.7495 |
Entamoeba histolytica | protein kinase, putative | 0.1194 | 0.0035 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.2036 | 0.1017 | 0.2505 |
Echinococcus granulosus | protein kinase c epsilon type | 0.2114 | 0.1107 | 0.2736 |
Loa Loa (eye worm) | hypothetical protein | 0.8542 | 0.8606 | 0.8602 |
Entamoeba histolytica | protein kinase, putative | 0.1194 | 0.0035 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Onchocerca volvulus | 0.8542 | 0.8606 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Toxoplasma gondii | AGC kinase | 0.1194 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3282 | 0.247 | 0.2444 |
Entamoeba histolytica | protein kinase, putative | 0.1194 | 0.0035 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4554 | 0.3955 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.2548 | 0.1614 | 0.1584 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.244 | 0.1488 | 0.3708 |
Echinococcus multilocularis | serine threonine protein kinase | 0.3713 | 0.2973 | 0.7495 |
Entamoeba histolytica | protein kinase, putative | 0.1194 | 0.0035 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.4554 | 0.3955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.9383 | 0.9588 | 0.9587 |
Brugia malayi | protein kinase C II. | 0.2114 | 0.1107 | 0.4188 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1194 | 0.0035 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 23.1 mM | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23072866 |
Ki (binding) | = 58.6 mM | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | ChEMBL. | 23072866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.