Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0225 | 0.1804 | 0.1777 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0361 | 0.4556 | 0.39 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0188 | 0.1076 | 0.1046 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.043 | 0.594 | 0.5926 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0225 | 0.1804 | 0.1777 |
Schistosoma mansoni | lipoxygenase | 0.0442 | 0.6173 | 0.5712 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0261 | 0.2531 | 0.2506 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0135 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.043 | 0.594 | 0.5926 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0632 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0261 | 0.2531 | 0.2506 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0135 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0632 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0188 | 0.1076 | 0.1046 |
Chlamydia trachomatis | glutamine binding protein | 0.0135 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0135 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0135 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0135 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0205 | 0.1417 | 0.1389 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | M | Inhibition of Beta-glucosidase of almond; NI denotes no inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of Alpha-fucosidase of bovine kidney; NI=no inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of Beta-galactosidase of bovine liver; NI=inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of alpha-mannosidase of Jack beans; NI denotes no inhibition | ChEMBL. | 15380224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.