Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamine binding protein | 0.0135 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0632 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0225 | 0.1804 | 0.1777 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0225 | 0.1804 | 0.1777 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0135 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0135 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.043 | 0.594 | 0.5926 |
Schistosoma mansoni | lipoxygenase | 0.0442 | 0.6173 | 0.5712 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0188 | 0.1076 | 0.1046 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0135 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.043 | 0.594 | 0.5926 |
Schistosoma mansoni | lipoxygenase | 0.0632 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0361 | 0.4556 | 0.39 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0261 | 0.2531 | 0.2506 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0188 | 0.1076 | 0.1046 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0135 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0135 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0261 | 0.2531 | 0.2506 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0205 | 0.1417 | 0.1389 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | M | Inhibition of alpha-mannosidase of Jack beans; NI denotes no inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of Beta-galactosidase of bovine liver; NI=inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of Alpha-fucosidase of bovine kidney; NI=no inhibition | ChEMBL. | 15380224 |
IC50 (binding) | M | Inhibition of Beta-glucosidase of almond; NI denotes no inhibition | ChEMBL. | 15380224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.