Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Onchocerca volvulus | 0.0154 | 0.415 | 1 | |
Schistosoma mansoni | P2X receptor subunit | 0.0142 | 0.3619 | 0.3286 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0154 | 0.415 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0287 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0287 | 1 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0154 | 0.415 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0496 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0496 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0496 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0287 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Schistosoma mansoni | P2X receptor subunit | 0.0287 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0142 | 0.3619 | 0.3286 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.415 | 0.3844 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0287 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.0496 | 0.0496 |
Schistosoma mansoni | P2X receptor subunit | 0.0287 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.028 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 0.028 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
GI50 (functional) | -4.774 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.768 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.759 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.753 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.746 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.738 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.714 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.675 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.652 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.532 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.