Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.1092 | 0.4945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus multilocularis | fibropellin Ia | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.035 | 0.0806 | 0.1718 |
Echinococcus granulosus | enteropeptidase | 0.035 | 0.0806 | 0.132 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.035 | 0.0806 | 0.132 |
Brugia malayi | Fibulin-1 precursor | 0.0637 | 0.2406 | 0.2113 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0272 | 0.0372 | 0.0792 |
Echinococcus granulosus | slit 2 protein | 0.0272 | 0.0372 | 0.035 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0479 | 0.1529 | 0.1202 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | neural cadherin | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.1718 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | protein jagged 1 | 0.0272 | 0.0372 | 0.035 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | protein jagged 2 | 0.0272 | 0.0372 | 0.035 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | notch | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus multilocularis | enteropeptidase | 0.035 | 0.0806 | 0.1718 |
Echinococcus granulosus | neural cadherin | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0479 | 0.1529 | 0.5 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Protein kinase domain containing protein | 0.0479 | 0.1529 | 0.1202 |
Echinococcus granulosus | fibropellin Ia | 0.0272 | 0.0372 | 0.035 |
Toxoplasma gondii | kringle domain-containing protein | 0.0479 | 0.1529 | 0.4507 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1047 | 0.4695 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1999 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1999 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Loa Loa (eye worm) | trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.1529 | 0.1343 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Echinococcus granulosus | laminin | 0.0637 | 0.2406 | 0.4891 |
Onchocerca volvulus | Arrow homolog | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0479 | 0.1529 | 0.3257 |
Echinococcus multilocularis | fibrillin 1 | 0.0637 | 0.2406 | 0.5125 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.035 | 0.0806 | 0.132 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0272 | 0.0372 | 0.035 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0637 | 0.2406 | 0.7922 |
Echinococcus granulosus | protein jagged 1 | 0.0272 | 0.0372 | 0.035 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | protein jagged 2 | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Toxoplasma gondii | PAN domain-containing protein | 0.0732 | 0.294 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.1092 | 0.4945 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.035 | 0.0806 | 0.1718 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Onchocerca volvulus | 0.1999 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0637 | 0.2406 | 0.5125 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1092 | 0.4945 | 1 |
Onchocerca volvulus | 0.1649 | 0.805 | 0.7975 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.035 | 0.0806 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1529 | 0.1202 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.035 | 0.0806 | 0.132 |
Schistosoma mansoni | egf-like domain protein | 0.0637 | 0.2406 | 0.2239 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | cell polarity protein | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.035 | 0.0806 | 0.0451 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1047 | 0.4695 | 1 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | slit | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | Tolloid protein 1 | 0.0637 | 0.2406 | 0.4891 |
Echinococcus granulosus | Mastin | 0.035 | 0.0806 | 0.132 |
Echinococcus multilocularis | laminin | 0.0637 | 0.2406 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Echinococcus multilocularis | protein jagged 1 | 0.0272 | 0.0372 | 0.0792 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0479 | 0.1529 | 0.2934 |
Leishmania major | hypothetical protein, conserved | 0.0479 | 0.1529 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0479 | 0.1529 | 0.1202 |
Echinococcus multilocularis | Coagulation factor 5 8 type, C terminal | 0.0244 | 0.0215 | 0.0458 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.1213 | 0.5617 | 0.5448 |
Schistosoma mansoni | septate junction protein | 0.031 | 0.0587 | 0.038 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.035 | 0.0806 | 0.1718 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2621 | 0.2336 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.2442 | 0.2151 |
Echinococcus multilocularis | protein jagged 1 | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus multilocularis | slit 2 protein | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0637 | 0.2406 | 0.7922 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Giardia lamblia | High cysteine protein | 0.0272 | 0.0372 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0704 | 0.278 | 0.2501 |
Echinococcus multilocularis | Mastin | 0.035 | 0.0806 | 0.1718 |
Brugia malayi | Trypsin-like protease protein 5 | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | delta-like protein 1 | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0637 | 0.2406 | 0.2239 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.278 | 0.2501 |
Toxoplasma gondii | PAN domain-containing protein | 0.0732 | 0.294 | 1 |
Onchocerca volvulus | 0.0479 | 0.1529 | 0.1202 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.1999 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1999 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0479 | 0.1529 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.2406 | 0.2113 |
Brugia malayi | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Mycobacterium ulcerans | hypothetical protein | 0.035 | 0.0806 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus granulosus | notch | 0.0272 | 0.0372 | 0.035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.