Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PAN domain-containing protein | 0.0732 | 0.294 | 1 |
Giardia lamblia | High cysteine protein | 0.0272 | 0.0372 | 0.5 |
Echinococcus granulosus | protein jagged 2 | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | notch | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | notch | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.1718 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1047 | 0.4695 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0637 | 0.2406 | 0.4891 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0479 | 0.1529 | 0.5 |
Echinococcus granulosus | delta-like protein 1 | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | Mastin | 0.035 | 0.0806 | 0.1718 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0479 | 0.1529 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.035 | 0.0806 | 0.0451 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | egf-like domain protein | 0.0637 | 0.2406 | 0.2239 |
Brugia malayi | Fibulin-1 precursor | 0.0637 | 0.2406 | 0.2113 |
Echinococcus multilocularis | protein jagged 2 | 0.0272 | 0.0372 | 0.0792 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1092 | 0.4945 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.035 | 0.0806 | 0.1718 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0704 | 0.278 | 0.2501 |
Echinococcus granulosus | laminin | 0.0637 | 0.2406 | 0.4891 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus granulosus | slit 2 protein | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Trypsin-like protease protein 5 | 0.035 | 0.0806 | 0.0451 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1047 | 0.4695 | 1 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.0806 | 0.0604 |
Echinococcus granulosus | protein jagged 1 | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.1529 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.0792 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1092 | 0.4945 | 1 |
Entamoeba histolytica | hypothetical protein | 0.1092 | 0.4945 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.035 | 0.0806 | 0.132 |
Onchocerca volvulus | 0.1999 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.1213 | 0.5617 | 0.5448 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Onchocerca volvulus | Arrow homolog | 0.0637 | 0.2406 | 0.2113 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus granulosus | neural cadherin | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.035 | 0.0806 | 0.1718 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Onchocerca volvulus | 0.1649 | 0.805 | 0.7975 | |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus granulosus | Mastin | 0.035 | 0.0806 | 0.132 |
Brugia malayi | Protein kinase domain containing protein | 0.0479 | 0.1529 | 0.1202 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1529 | 0.1202 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | protein jagged 1 | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.035 | 0.0806 | 0.1718 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | protein jagged 1 | 0.0272 | 0.0372 | 0.0792 |
Toxoplasma gondii | kringle domain-containing protein | 0.0479 | 0.1529 | 0.4507 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.2621 | 0.2336 |
Onchocerca volvulus | 0.0479 | 0.1529 | 0.1202 | |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0479 | 0.1529 | 0.2934 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | slit | 0.0272 | 0.0372 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.035 | 0.0806 | 0.0604 |
Leishmania major | hypothetical protein, conserved | 0.0479 | 0.1529 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.035 | 0.0806 | 0.132 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | septate junction protein | 0.031 | 0.0587 | 0.038 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0637 | 0.2406 | 0.7922 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus granulosus | protein jagged 2 | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0637 | 0.2406 | 0.5125 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0637 | 0.2406 | 0.2113 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Kringle domain containing protein | 0.0479 | 0.1529 | 0.1202 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.035 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Schistosoma mansoni | cell polarity protein | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Toxoplasma gondii | PAN domain-containing protein | 0.0732 | 0.294 | 1 |
Brugia malayi | hypothetical protein | 0.035 | 0.0806 | 0.0451 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0637 | 0.2406 | 0.7922 |
Echinococcus granulosus | enteropeptidase | 0.035 | 0.0806 | 0.132 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Echinococcus granulosus | fibropellin Ia | 0.0272 | 0.0372 | 0.035 |
Mycobacterium ulcerans | hypothetical protein | 0.035 | 0.0806 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.2406 | 0.2113 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.2442 | 0.2151 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.035 | 0.0806 | 0.132 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.035 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0272 | 0.0372 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | laminin | 0.0637 | 0.2406 | 0.5125 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0479 | 0.1529 | 0.1202 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0637 | 0.2406 | 0.2113 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.035 | 0.0806 | 0.132 |
Echinococcus multilocularis | Coagulation factor 5 8 type, C terminal | 0.0244 | 0.0215 | 0.0458 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0272 | 0.0372 | 0.035 |
Echinococcus multilocularis | fibrillin 1 | 0.0637 | 0.2406 | 0.5125 |
Echinococcus multilocularis | neural cadherin | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1999 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1999 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0272 | 0.0372 | 0.0792 |
Echinococcus multilocularis | slit 2 protein | 0.0272 | 0.0372 | 0.0792 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1999 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.1999 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0637 | 0.2406 | 0.2239 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.278 | 0.2501 |
Echinococcus multilocularis | fibropellin Ia | 0.0272 | 0.0372 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.2406 | 0.2113 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0637 | 0.2406 | 0.2113 |
Onchocerca volvulus | 0.035 | 0.0806 | 0.0451 | |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.0372 | 0.016 |
Brugia malayi | Trypsin family protein | 0.035 | 0.0806 | 0.0451 |
Echinococcus granulosus | protein jagged 1 | 0.0272 | 0.0372 | 0.035 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.2406 | 0.2113 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0479 | 0.1529 | 0.3257 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.035 | 0.0806 | 0.0604 |
Schistosoma mansoni | notch | 0.0272 | 0.0372 | 0.016 |
Echinococcus multilocularis | enteropeptidase | 0.035 | 0.0806 | 0.1718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.