Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Phospho-N-acetylmuramoyl-pentapeptide-transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0511 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0511 | 1 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0154 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0154 | 0 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0154 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0154 | 0 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0511 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0511 | 1 | 0.5 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0511 | 1 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0154 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4000 nM | Inhibition of Staphylococcus aureus MraY using UDP-MurNAc-dansylpentapeptide substrate assessed as formation of dansylated lipid I incubated for 3 to 4 hrs by fluorometric assay | ChEMBL. | 22677318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.