Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3255 | 1 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.0003 | 0.00000014065 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0023 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | Death domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0023 | 0.0832 | 0.2556 | |
Onchocerca volvulus | Netrin receptor homolog | 0.0017 | 0.0003 | 0.0008 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.0832 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0023 | 0.0071 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0023 | 0.0832 | 0.2556 | |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.0003 | 0.00000014065 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.0003 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0023 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0023 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.3255 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0003 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0003 | 0.0008 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 195 nM | Inhibition of CETP in human plasma assessed as transfer of fluorescently labelled cholesteryl ester to VLDL by fluorimetry | ChEMBL. | 22543028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.