Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7349 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.6863 | 0.9339 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0124 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0629 | 0.0916 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.126 | 0.1715 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0124 | 0.018 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.6863 | 0.9339 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.126 | 0.1715 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0629 | 0.0856 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.6863 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.6863 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0629 | 0.0856 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0124 | 0.0168 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0124 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0629 | 0.0856 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.6863 | 0.9339 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0124 | 0.0168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0629 | 0.0856 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0124 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0629 | 0.0916 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0059 | 0.126 | 0.1715 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7349 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0059 | 0.126 | 0.126 |
Echinococcus multilocularis | geminin | 0.0173 | 0.7349 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.6863 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.126 | 0.1837 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.6863 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0124 | 0.0981 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.6863 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0629 | 0.0856 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.6863 | 0.9339 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0124 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0124 | 0.0981 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.6863 | 0.9339 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0124 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0124 | 0.0168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0629 | 0.0856 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0124 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.6863 | 0.9339 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0059 | 0.126 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0124 | 0.018 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.126 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.126 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0124 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0629 | 0.0856 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.1051 | 0.1531 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0124 | 0.0168 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.6863 | 0.9339 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0124 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.0173 | 0.7349 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.6863 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.