Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0284 | 0.0313 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0284 | 0.0313 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0362 | 0.0412 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0362 | 0.0412 | 0.2108 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0284 | 0.0313 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0284 | 0.0313 | 0.6877 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0284 | 0.0313 | 0.5 |
Leishmania major | protein kinase, putative | 0.0284 | 0.0313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1578 | 0.1956 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0284 | 0.0313 | 0.6877 |
Brugia malayi | serine/threonine kinase 12 | 0.0284 | 0.0313 | 0.1599 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0362 | 0.0412 | 1 |
Toxoplasma gondii | aurora kinase | 0.0284 | 0.0313 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0284 | 0.0313 | 1 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0094 | 0.0479 |
Echinococcus multilocularis | thymidine phosphorylase | 0.7917 | 1 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0284 | 0.0313 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0284 | 0.0313 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0284 | 0.0313 | 0.6877 |
Loa Loa (eye worm) | AUR protein kinase | 0.0284 | 0.0313 | 0.1599 |
Loa Loa (eye worm) | AUR protein kinase | 0.0284 | 0.0313 | 0.1599 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0284 | 0.0313 | 0.1599 |
Entamoeba histolytica | protein kinase , putative | 0.0284 | 0.0313 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0284 | 0.0313 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.7917 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0362 | 0.0412 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0284 | 0.0313 | 0.6877 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0284 | 0.0313 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0284 | 0.0313 | 0.1599 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.2235 | 0.2789 | 0.2789 |
Entamoeba histolytica | protein kinase, putative | 0.0284 | 0.0313 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0362 | 0.0412 | 0.0103 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0284 | 0.0313 | 0.1599 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0094 | 0.0479 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0362 | 0.0412 | 0.0103 |
Loa Loa (eye worm) | TTK protein kinase | 0.0362 | 0.0412 | 0.2108 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0362 | 0.0412 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0362 | 0.0412 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.7917 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1578 | 0.1956 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.2235 | 0.2789 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Escherichia coli NIHJ JC-2 | ChEMBL. | 6422043 |
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Escherichia coli NIHJ JC-2 | ChEMBL. | 6422043 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Staphylococcus aureus 209PJC-1 | ChEMBL. | 6422043 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa Tsuchijima | ChEMBL. | 6422043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.