Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 437 aa | 397 aa | 28.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0184 | 0.4675 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0184 | 0.4675 | 1 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0184 | 0.4675 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0026 | 0.0099 | 1 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0026 | 0.0099 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0367 | 1 | 1 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0184 | 0.4675 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0026 | 0.0099 | 0.5 |
Echinococcus multilocularis | Aminotransferase class III | 0.0026 | 0.0099 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0184 | 0.4675 | 1 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0026 | 0.0099 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0026 | 0.0099 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 1 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0026 | 0.0099 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0026 | 0.0099 | 0.5 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0184 | 0.4675 | 1 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0026 | 0.0099 | 0.0099 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0026 | 0.0099 | 1 |
Echinococcus granulosus | ornithine aminotransferase | 0.0026 | 0.0099 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0026 | 0.0099 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | 4.17 uM | PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.