Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0515 | 0.0383 |
Entamoeba histolytica | hexokinase 1 | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.055 | 0.6741 | 0.6696 |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0506 | 0.6181 | 0.6181 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0807 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0515 | 0.0383 |
Schistosoma mansoni | hexokinase | 0.0807 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0257 | 0.3009 | 0.3009 |
Toxoplasma gondii | hexokinase | 0.0807 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0807 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0515 | 0.0515 |
Brugia malayi | Hexokinase family protein | 0.025 | 0.2922 | 0.2922 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0273 | 0.0138 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0515 | 0.0515 |
Brugia malayi | hypothetical protein | 0.003 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hexokinase type II | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Trypanosoma brucei | hexokinase, putative | 0.0807 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0506 | 0.6181 | 0.6128 |
Loa Loa (eye worm) | hexokinase | 0.025 | 0.2922 | 0.2823 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.