Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0273 | 0.0273 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0273 | 0.0138 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.0807 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0807 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0506 | 0.6181 | 0.6181 |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3009 | 0.2912 |
Brugia malayi | Hexokinase family protein | 0.025 | 0.2922 | 0.2922 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.025 | 0.2922 | 0.2823 |
Entamoeba histolytica | hexokinase 2 | 0.0807 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0515 | 0.0383 |
Trypanosoma cruzi | hexokinase, putative | 0.0807 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0257 | 0.3009 | 0.3009 |
Plasmodium vivax | hexokinase, putative | 0.0807 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.055 | 0.6741 | 0.6696 |
Entamoeba histolytica | hexokinase 1 | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0506 | 0.6181 | 0.6128 |
Onchocerca volvulus | 0.0807 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0807 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0807 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0137 | 0.0137 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0807 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0807 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0515 | 0.0383 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0515 | 0.0515 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0515 | 0.0515 |
Echinococcus multilocularis | hexokinase type 2 | 0.0807 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.