Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0048 | 0.3736 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0048 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | nuclear hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | coup transcription factor | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0048 | 0.3736 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0048 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0048 | 0.3736 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.3736 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | nuclear receptor NHR-88 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | thyroid hormone receptor | 0.0048 | 0.3736 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.3736 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.3736 | 0.5 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0048 | 0.3736 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0048 | 0.3736 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0048 | 0.3736 | 0.3736 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0048 | 0.3736 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0048 | 0.3736 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.3736 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.