Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.1083 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.1083 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.1083 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.1083 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 1 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.1083 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 1 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | 0.0064 | 0.2679 | 0.2666 | |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.