Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | malate dehydrogenase MDH | 0.098 | 1 | 0.5 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.098 | 1 | 1 |
Leishmania major | glycosomal malate dehydrogenase | 0.0764 | 0.7621 | 0.4439 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.098 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.098 | 1 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.098 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Echinococcus multilocularis | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Giardia lamblia | Malate dehydrogenase | 0.0829 | 0.8334 | 0.5 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.098 | 1 | 1 |
Leishmania major | malate dehydrogenase | 0.0764 | 0.7621 | 0.4439 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.098 | 1 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Loa Loa (eye worm) | hypothetical protein | 0.098 | 1 | 1 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0829 | 0.8334 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.098 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.098 | 1 | 1 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0764 | 0.7621 | 0.7271 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0592 | 0.5723 | 0.5611 |
Plasmodium vivax | lactate dehydrogenase | 0.098 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.098 | 1 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.098 | 1 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.098 | 1 | 0.5 |
Leishmania major | malate dehydrogenase, putative | 0.098 | 1 | 1 |
Leishmania major | mitochondrial malate dehydrogenase | 0.0764 | 0.7621 | 0.4439 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0389 | 0.3491 | 0.3491 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0389 | 0.3491 | 0.3491 |
Plasmodium vivax | malate dehydrogenase, putative | 0.098 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0592 | 0.5723 | 0.5723 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0525 | 0.4996 | 0.4389 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0829 | 0.8334 | 0.5 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0764 | 0.7621 | 0.7271 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.098 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0764 | 0.7621 | 0.7271 |
Echinococcus granulosus | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0764 | 0.7621 | 0.7271 |
Schistosoma mansoni | malate dehydrogenase | 0.098 | 1 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Brugia malayi | Probable malate dehydrogenase, mitochondrial precursor | 0.0764 | 0.7621 | 0.7621 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0764 | 0.7621 | 0.7271 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.098 | 1 | 0.5 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Brugia malayi | Malate dehydrogenase, cytoplasmic | 0.0829 | 0.8334 | 0.8334 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.098 | 1 | 0.5 |
Schistosoma mansoni | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Leishmania major | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 0.6105 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.098 | 1 | 1 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 1 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0829 | 0.8334 | 1 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0764 | 0.7621 | 0.7271 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0829 | 0.8334 | 0.8334 |
Echinococcus multilocularis | malate dehydrogenase | 0.0764 | 0.7621 | 0.7621 |
Chlamydia trachomatis | malate dehydrogenase | 0.0829 | 0.8334 | 0.5 |
Plasmodium falciparum | malate dehydrogenase | 0.098 | 1 | 1 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0829 | 0.8334 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 23.6 % | The hypoglycemic activity in diabetic KK mice,activity expressed as % decrease in blood glucose (21h) | ChEMBL. | 10956213 |
Decrease (functional) | = 29.7 % | The hypoglycemic activity in diabetic KK mice,activity expressed as % decrease in blood glucose (18 h) | ChEMBL. | 10956213 |
EC (functional) | = 0.078 uM | Stimulation of adipogenesis in 3T3-L1 cells is expressed as concentration equivalent to the [ 1-14C] uptake counts after treatment with 0.2 ug/mL troglitazone | ChEMBL. | 10956213 |
EC (functional) | = 0.078 uM | Stimulation of adipogenesis in 3T3-L1 cells is expressed as concentration equivalent to the [ 1-14C] uptake counts after treatment with 0.2 ug/mL troglitazone | ChEMBL. | 10956213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.