Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.6967 | 0.6516 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0051 | 0.3761 | 0.5 |
Brugia malayi | Peroxidasin | 0.0078 | 0.6967 | 0.6967 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0037 | 0.2068 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.6967 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.6967 | 0.6967 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0051 | 0.3761 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.6967 | 0.6967 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1297 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.6967 | 0.6967 |
Echinococcus granulosus | peroxidasin | 0.0078 | 0.6967 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.6967 | 0.6516 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0056 | 0.4414 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0056 | 0.4414 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0078 | 0.6967 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0078 | 0.6967 | 0.5 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0103 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1297 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.6967 | 0.5 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0037 | 0.2068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Onchocerca volvulus | 0.0078 | 0.6967 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.4414 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0078 | 0.6967 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0078 | 0.6967 | 0.6967 |
Onchocerca volvulus | 0.0078 | 0.6967 | 0.5 | |
Brugia malayi | hypothetical protein | 0.003 | 0.1297 | 0.1297 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.6967 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1297 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.6967 | 0.6967 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.6967 | 0.6967 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.2068 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1297 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.6967 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Brugia malayi | hypothetical protein | 0.0078 | 0.6967 | 0.6967 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0037 | 0.2068 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0056 | 0.4414 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.6967 | 0.6516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6967 | 0.6516 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.6967 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.