Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.1465 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.1597 | 0.0277 | 0.0296 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.6063 | 0.9638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5926 | 0.935 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.2863 | 0.2931 | 0.1206 |
Echinococcus multilocularis | adam 17 protease | 0.6063 | 0.9638 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.3373 | 0.3999 | 0.2654 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.2863 | 0.2931 | 0.1263 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.2863 | 0.2931 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.3373 | 0.3999 | 0.2534 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1465 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.