Detailed information for compound 170686

Basic information

Technical information
  • TDR Targets ID: 170686
  • Name: 2-(3-hydroxyphenyl)-[1,2]thiazolo[5,4-b]pyrid in-3-one
  • MW: 244.269 | Formula: C12H8N2O2S
  • H donors: 1 H acceptors: 3 LogP: 1.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)n1sc2c(c1=O)cccn2
  • InChi: 1S/C12H8N2O2S/c15-9-4-1-3-8(7-9)14-12(16)10-5-2-6-13-11(10)17-14/h1-7,15H
  • InChiKey: IZWYAECJIVYUJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-hydroxyphenyl)isothiazolo[5,4-b]pyridin-3-one
  • 2-(3-hydroxyphenyl)-3-isothiazolo[5,4-b]pyridinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.3986 0.4096
Loa Loa (eye worm) hypothetical protein 0.0044 0.4761 0.4898
Schistosoma mansoni hypothetical protein 0.0068 0.7926 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.3986 0.3971
Entamoeba histolytica protein kinase, putative 0.0008 0.0024 0.5
Brugia malayi hypothetical protein 0.0066 0.7622 0.7616
Echinococcus granulosus jun protein 0.0084 1 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.3986 0.3971
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.417 0.4287
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.096 0.0968
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.6019 0.6009
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.9696 1
Echinococcus granulosus protein kinase C gamma type 0.0048 0.5243 0.5232
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 1 1
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.096 0.1185
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.096 0.0939
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.3986 0.3971
Entamoeba histolytica protein kinase, putative 0.0008 0.0024 0.5
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0799 0.0777
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.6019 0.7587
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Toxoplasma gondii AGC kinase 0.0008 0.0024 0.5
Onchocerca volvulus 0.0066 0.7622 0.5
Trypanosoma brucei rac serine-threonine kinase, putative 0.0008 0.0024 0.5
Entamoeba histolytica protein kinase, putative 0.0008 0.0024 0.5
Entamoeba histolytica protein kinase, putative 0.0008 0.0024 0.5
Echinococcus multilocularis jun protein 0.0084 1 1
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.5243 0.5232
Brugia malayi Protein kinase c protein 2 0.0046 0.4946 0.4934
Schistosoma mansoni atypical protein kinase C 0.0014 0.0799 0.0981
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Brugia malayi protein kinase C II. 0.0015 0.096 0.0939
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.6019 0.7587
Echinococcus granulosus protein kinase c iota type 0.0014 0.0799 0.0777
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.6019 0.6009
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.096 0.0939
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1
Schistosoma mansoni jun-related protein 0.0068 0.7926 1
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0024 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 21 uM In vitro inhibition of human recombinant IL-1beta-induced breakdown of bovine cartilage in a cartilage organ culture assay ChEMBL. 7932530

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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