Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.041 | 0.041 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.171 | 0.2211 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.7735 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.041 | 0.041 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0124 | 0.0124 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.0981 | 0.1268 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0124 | 0.0124 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.041 | 0.041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.041 | 0.041 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.041 | 0.053 |
Giardia lamblia | Hypothetical protein | 0.0442 | 0.6377 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.171 | 0.171 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0981 | 0.1268 |
Brugia malayi | Fibroblast growth factor family protein | 0.0442 | 0.6377 | 0.8244 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0147 | 0.171 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0314 | 0.0314 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0671 | 1 | 1 |
Brugia malayi | Fibroblast growth factor family protein | 0.0442 | 0.6377 | 0.8244 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0053 | 0.0224 | 0.0224 |
Brugia malayi | hypothetical protein | 0.0528 | 0.7735 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0124 | 0.0124 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0314 | 0.0314 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0314 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0474 | 0.0474 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0314 | 0.0314 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0314 | 0.1835 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.171 | 0.171 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.6377 | 0.8244 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.171 | 0.2211 |
Leishmania major | carbonic anhydrase-like protein | 0.0147 | 0.171 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.0981 | 0.1268 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0357 | 0.5037 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0314 | 0.0314 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.171 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.041 | 0.041 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0314 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0124 |
Brugia malayi | RNA binding protein | 0.0065 | 0.041 | 0.053 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 0.0989 | 0.1963 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.171 | 0.2211 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.041 | 0.053 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.171 | 0.171 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.014 | 0.014 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.041 | 0.053 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0671 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.458 | 0.458 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.041 | 0.053 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.171 | 0.2211 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.171 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.041 | 0.041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0124 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0124 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0124 | 0.016 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.041 | 0.053 |
Onchocerca volvulus | 0.0048 | 0.014 | 0.5 | |
Mycobacterium ulcerans | hydrolase/amidase | 0.0276 | 0.3756 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0124 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.6377 | 0.8244 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0474 | 0.0613 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0124 | 0.0124 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.458 | 0.458 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0102 | 0.0989 | 0.1963 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.171 | 0.171 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0474 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.014 | 0.0181 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.041 | 0.041 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.0981 | 0.1268 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.000000011 M | Inhibition of human erythrocyte carbonic anhydrase II | ChEMBL. | 1501230 |
IC50 (binding) | = 0.000000011 M | Inhibition of human erythrocyte carbonic anhydrase II | ChEMBL. | 1501230 |
Inhibition (functional) | = 47 % | Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo | ChEMBL. | 1501230 |
Inhibition (functional) | = 47 % | Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo | ChEMBL. | 1501230 |
Inhibition (functional) | = 91 % | Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo | ChEMBL. | 1501230 |
Inhibition (functional) | = 91 % | Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo | ChEMBL. | 1501230 |
PC | = 1.04 | Partition coefficient(PC) was determined by equilibrating compound between 1-octanol and 0.1 ionic strength pH 7.4 buffer | ChEMBL. | 1501230 |
Pigment binding (functional) | = 73 % | Percentage binding of the compound to bovine iris and ciliary body | ChEMBL. | 1501230 |
pKa | = 7 | pKa of the compound was determined in water | ChEMBL. | 1501230 |
pKa | = 9.05 | pKa of the compound was determined in 30% ethanol | ChEMBL. | 1501230 |
Solubility | > 27 mg ml-1 | Solubility of the compound was evaluated in water at 25 degree centigrade | ChEMBL. | 1501230 |
Solubility | > 27 mg ml-1 | Solubility of the compound was evaluated at pH 7.4 buffer at 25 degree centigrade | ChEMBL. | 1501230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.