Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Oryza sativa | Os01g0286600 | Starlite/ChEMBL | No references |
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | protoporphyrinogen oxidase | Protoporphyrinogen IX oxidase | 535 aa | 458 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0576 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.05 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0576 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0576 | 1 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0576 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.05 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (ADMET) | > 10 % | Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay | ChEMBL. | 19772294 |
GI (ADMET) | > 10 % | Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay | ChEMBL. | 16190649 |
IC50 (binding) | = 8.4 | Inhibition of protoporphyrinogen-9 oxidase in Echinochloa esculenta seed after 5 min by Dixon plot analysis | ChEMBL. | No reference |
IC50 (binding) | = 8.49 | Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluorescence spectroscopy | ChEMBL. | 18808144 |
IC50 (binding) | = 8.5 | Inhibition of protoporphyrinogen IX oxidase in Zea mays (maize) seed after 5 min by Dixon plot analysis | ChEMBL. | No reference |
Potency (functional) | 43.2771 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 43.2771 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 68.5896 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.