Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hepatocyte nuclear factor 4, alpha | Starlite/ChEMBL | No references |
Homo sapiens | perilipin 1 | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.6754 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.6754 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.6754 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.6754 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.6754 | 0.7254 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0135 | 0.9244 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.6754 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.6754 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.6754 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.6754 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 2.32 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 2.54 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9935 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.