Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Trypanosoma brucei | aurora B kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.0722 |
Echinococcus granulosus | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0169 | 0.0017 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | protein kinase , putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.3412 | 0.3412 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0591 | 0.0591 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0372 | 0.0372 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0191 | 0.2198 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.156 | 0.156 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Onchocerca volvulus | 0.0033 | 0.0372 | 0.0103 | |
Trypanosoma cruzi | aurora B kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0483 | 0.0483 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0664 | 1 | 1 |
Onchocerca volvulus | 0.0291 | 0.4298 | 0.4138 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0169 | 0.0168 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0191 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.156 | 0.156 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0191 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.1586 | 0.1586 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0664 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Onchocerca volvulus | 0.0265 | 0.3902 | 0.3732 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Plasmodium vivax | RNA helicase-1, putative | 0.0664 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0272 | 0.0122 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2818 | 0.2818 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3902 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.156 | 0.156 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0272 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0591 | 0.0591 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0755 | 0.0755 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0591 | 0.0591 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.3412 | 0.3412 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Schistosoma mansoni | protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0664 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0194 | 0.2818 | 0.2818 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0169 | 0.0168 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0664 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0272 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0483 | 0.0483 |
Brugia malayi | serine/threonine kinase 12 | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Giardia lamblia | Aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0354 | 0.0353 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0135 | 0.0135 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0272 | 0.0122 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Toxoplasma gondii | aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0722 | 0.0722 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0272 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0169 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.