Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.2997 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.2997 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2997 | 0.2997 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3094 | 0.3094 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0059 | 0.2997 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0059 | 0.2997 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 0.2997 | 1 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.2445 | 0.5 |
Treponema pallidum | flavodoxin | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0036 | 0.114 | 0.114 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0036 | 0.114 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0059 | 0.2997 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0059 | 0.2997 | 0.2997 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1528 | 0.1528 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.2997 | 1 |
Leishmania major | p450 reductase, putative | 0.0059 | 0.2997 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.0552 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.2997 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0052 | 0.2445 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.2997 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0059 | 0.2997 | 0.2997 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 0.2997 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0036 | 0.114 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0059 | 0.2997 | 0.2997 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3094 | 0.3094 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0059 | 0.2997 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0052 | 0.2445 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0036 | 0.114 | 0.114 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0059 | 0.2997 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0059 | 0.2997 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.2997 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.2445 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.0552 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0059 | 0.2997 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0059 | 0.2997 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0059 | 0.2997 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0059 | 0.2997 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.003 | 0.0589 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1528 | 0.3992 |
Leishmania major | cytochrome P450 reductase, putative | 0.0052 | 0.2445 | 0.8159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.