Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 1 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 1 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 1 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 1 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 1 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.5598 | 0.5598 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 3.017 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 7.578 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.