Detailed information for compound 1710940

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.45 | Formula: C20H20N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1cccc(c1)c1csc(n1)C(c1ccccc1)NC(=O)C
  • InChi: 1S/C20H20N2O2S/c1-14(23)21-19(16-8-4-3-5-9-16)20-22-18(13-25-20)17-10-6-7-15(11-17)12-24-2/h3-11,13,19H,12H2,1-2H3,(H,21,23)
  • InChiKey: SGHOKMHPTDWBCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0034 0.0224 0.1166
Brugia malayi G protein-coupled receptor 0.0034 0.0224 0.0224
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0283 0.2812 0.3652
Schistosoma mansoni opsin-like receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0273
Entamoeba histolytica hypothetical protein 0.0072 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0824 0.1384
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0224 0.0291
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0224 0.0377
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0587 0.5953 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0587 0.5953 0.7732
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus multilocularis inhibitor of apoptosis protein 0.0054 0.043 0.0723
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0096 0.5
Echinococcus granulosus g protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0824 0.107
Schistosoma mansoni amine GPCR 0.0034 0.0224 0.0377
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0224 0.0377
Echinococcus granulosus GPCR family 2 0.0033 0.0215 0.036
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0224 0.0377
Schistosoma mansoni neuropeptide receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0224 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0587 0.5953 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Entamoeba histolytica hypothetical protein 0.0072 0.0616 1
Brugia malayi larval opioid receptor 0.0034 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0377
Schistosoma mansoni amine GPCR 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.036
Echinococcus multilocularis sex peptide receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0284 0.2822 0.3665
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0224 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni transient receptor potential channel 0.0063 0.0529 0.0889
Entamoeba histolytica hypothetical protein 0.0023 0.0118 0.0432
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0494 0.0829
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0824 0.1384
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1235 0.2075
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0054 0.043 0.0723
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0224 0.0377
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0224 0.0377
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0824 0.1384
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.0227
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0387 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.0529 0.0889
Echinococcus granulosus fmrfamide receptor 0.0034 0.0224 0.0377
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0224 0.0377
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0587 0.5953 1
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0824 0.1384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni hypothetical protein 0.0054 0.043 0.0723
Loa Loa (eye worm) hypothetical protein 0.0386 0.3874 0.5032
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0224 0.0224
Echinococcus granulosus biogenic amine 5HT receptor 0.0283 0.2812 0.4723
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0494 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0224 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0387 0.0503
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0072 0.0616 0.0616
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0224 0.0377
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.0224 0.0291
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.0224 0.0377
Brugia malayi Dopamine receptor 0.0034 0.0224 0.0224
Onchocerca volvulus 0.0034 0.0224 0.1166
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Brugia malayi hypothetical protein 0.0049 0.0387 0.0387
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0118 1
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.0224 0.0377
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0529 0.0889
Brugia malayi AKH receptor 0.0034 0.0224 0.0224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0215 0.036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0315
Onchocerca volvulus 0.0034 0.0224 0.1166
Schistosoma mansoni biogenic amine receptor 0.0034 0.0224 0.0377
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.036
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0224 0.0291
Entamoeba histolytica hypothetical protein 0.0072 0.0616 1
Echinococcus multilocularis snurportin 1 0.0309 0.3078 0.5171
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi sulfakinin receptor protein 0.0034 0.0224 0.0224
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1235 0.2075
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1235 0.2075
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.0224 0.0224
Brugia malayi Serine/threonine-protein kinase SULU 0.0587 0.5953 0.5953
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0224 0.0377
Brugia malayi RNA, U transporter 1 0.0082 0.0728 0.0728
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0224 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni inhibitor of apoptosis protein 0.0054 0.043 0.0723
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0095 0.0864 0.1122
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0494 0.0829
Leishmania major hypothetical protein, conserved 0.0049 0.0387 0.0383
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0224 0.0377
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0224 0.0377
Leishmania major C-8 sterol isomerase-like protein 0.0755 0.7699 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0494 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0529 0.0889
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus g protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0175 0.0294
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0755 0.7699 0.7699
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0224 0.0377
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0105 0.0176
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0224 0.0224
Onchocerca volvulus 0.0034 0.0224 0.1166
Onchocerca volvulus 0.0034 0.0224 0.1166
Brugia malayi Importin beta-1 subunit 0.0029 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0034 0.0224 0.1166
Onchocerca volvulus 0.0034 0.0224 0.1166
Echinococcus multilocularis serotonin receptor 0.0283 0.2812 0.4723
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0831 0.1396
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0494 0.0829
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus importin subunit beta 1 0.0029 0.0175 0.0294
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1235 0.1235
Echinococcus granulosus orexin receptor type 2 0.0034 0.0224 0.0377
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1235 0.2075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0224 0.0377
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0224 0.0377
Brugia malayi GnHR receptor homolog 0.0034 0.0224 0.0224
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0616 0.1035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0224 0.0377
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0529 0.0889
Schistosoma mansoni neuropeptide receptor 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0054 0.043 0.2238
Schistosoma mansoni adenoreceptor 0.0034 0.0224 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0224 0.0291
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0118 0.003
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0224 0.0224
Onchocerca volvulus 0.0034 0.0224 0.1166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.043 0.043
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0529 0.0889
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0224 0.0377
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0616 0.1035
Brugia malayi RE15519p 0.0034 0.0224 0.0224
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0609 0.0609
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0864 0.1452
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.043 0.043
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0224 0.0377
Brugia malayi RNA binding protein 0.0131 0.1235 0.1235
Schistosoma mansoni neuropeptide receptor 0.0034 0.0224 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0824 0.0824
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0948 0.0948
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0054 0.043 0.0559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0224 0.0377
Schistosoma mansoni opsin-like receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0054 0.043 0.0723
Echinococcus granulosus snurportin 1 0.0309 0.3078 0.5171
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1235 0.1605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0824 0.1384
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0387 0.0383
Schistosoma mansoni hypothetical protein 0.0072 0.0616 0.1035
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0243 0.0408
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0215 0.036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0948 0.0948
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0224 0.0377
Leishmania major importin beta-1 subunit, putative 0.0023 0.0118 0.003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Onchocerca volvulus 0.0034 0.0224 0.1166
Brugia malayi G-protein coupled receptor 0.0034 0.0224 0.0224
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0224 0.1166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0224 0.0377
Echinococcus granulosus tar DNA binding protein 0.0131 0.1235 0.2075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0175 0.0104
Echinococcus granulosus neuropeptide receptor 0.0034 0.0224 0.0377
Trypanosoma brucei C-8 sterol isomerase, putative 0.0755 0.7699 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0224 0.0377
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.0224 0.0377
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0096 0.0161
Onchocerca volvulus 0.0034 0.0224 0.1166
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0054 0.043 0.0723
Echinococcus granulosus neuropeptide receptor 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0032 0.0206 0.0206
Brugia malayi neuropeptide F receptor 0.0034 0.0224 0.0224
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0387 0.7325
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0387 1
Schistosoma mansoni hypothetical protein 0.0071 0.0609 0.1022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0224 0.0377
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0948 0.1232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus allatostatin A receptor 0.0034 0.0224 0.0377
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0864 0.1452
Brugia malayi Dopamine receptor protein 2 0.0034 0.0224 0.0224
Brugia malayi putative neuropeptide receptor 0.0034 0.0224 0.0224
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0096 0.0124
Brugia malayi Melatonin receptor type 1A 0.0034 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0224 0.0377
Brugia malayi neuropeptide F receptor 0.0034 0.0224 0.0224
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0224 0.0377
Schistosoma mansoni biogenic amine receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni myosin xvIII 0.0034 0.0224 0.0377
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0215 0.036
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0224 0.0377
Brugia malayi G-protein coupled receptor 0.0034 0.0224 0.0224
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0034 0.0224 0.1166
Onchocerca volvulus 0.0034 0.0224 0.1166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0224 0.0291
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.036
Schistosoma mansoni ran 0.0021 0.0096 0.0161
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0377
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0175 0.1991
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0224 0.0377
Schistosoma mansoni hypothetical protein 0.0309 0.3078 0.5171
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0243 0.0243
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0494 0.0523
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0224 0.0377
Brugia malayi N-terminal motif family protein 0.0198 0.1922 0.1922
Brugia malayi Serotonin receptor 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0096 0.0161
Brugia malayi hypothetical protein 0.0587 0.5953 0.5953
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0215 0.0279
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0494 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0387 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0824 0.1384
Loa Loa (eye worm) hypothetical protein 0.0104 0.0948 0.1232
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0105 0.0176
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0224 0.0224
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0118 1
Echinococcus granulosus g protein coupled receptor 0.0034 0.0224 0.0377
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0224 0.0377
Schistosoma mansoni biogenic amine (5HT) receptor 0.0283 0.2812 0.4723
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0224 0.0377
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0224 0.1166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0224 0.0377
Schistosoma mansoni biogenic amine receptor 0.0034 0.0224 0.0377
Schistosoma mansoni importin beta-1 0.0029 0.0175 0.0294
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0215 0.0215
Onchocerca volvulus 0.0034 0.0224 0.1166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0175 0.0104
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0224 0.0377
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0224 0.0377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0494 0.0829
Echinococcus granulosus neuropeptide s receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Entamoeba histolytica hypothetical protein 0.0072 0.0616 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.3078 0.3998
Schistosoma mansoni amine GPCR 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0034 0.0224 0.1166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0224 0.0224
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0224 0.0291
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0224 0.0291
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0224 0.0377
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.1922 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0755 0.7699 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0755 0.7699 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0224 0.0377
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0243 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1235 0.2075
Schistosoma mansoni transient receptor potential channel 0.0095 0.0864 0.1452
Loa Loa (eye worm) hypothetical protein 0.0198 0.1922 0.2497
Brugia malayi follicle stimulating hormone receptor 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0054 0.043 0.0559
Echinococcus granulosus serotonin receptor 0.0034 0.0224 0.0377
Plasmodium vivax importin-beta 2, putative 0.0029 0.0175 0.2717
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0387 0.0383
Echinococcus multilocularis serotonin receptor 0.0283 0.2812 0.4723
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0864 0.1452
Echinococcus granulosus inhibitor of apoptosis protein 0.0054 0.043 0.0723
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0224 0.0224
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0224 0.0377
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0224 0.0377
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0616 0.1035
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0224 0.0377
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.006 0.0496 0.0645
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0034 0.0224 0.1166
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0224 0.0377
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0387 0.0383
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0494 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0224 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni amine GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni amine GPCR 0.0034 0.0224 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1235 0.2075
Schistosoma mansoni opsin-like receptor 0.0034 0.0224 0.0377
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) RNA binding protein 0.0131 0.1235 0.1605
Onchocerca volvulus 0.0034 0.0224 0.1166
Plasmodium falciparum importin beta, putative 0.0029 0.0175 0.2717
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0224 0.0377
Echinococcus granulosus hypothetical protein 0.0034 0.0224 0.0377
Brugia malayi TAR-binding protein 0.0131 0.1235 0.1235
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0224 0.0377
Schistosoma mansoni hypothetical protein 0.0022 0.0105 0.0176
Schistosoma mansoni hypothetical protein 0.0034 0.0224 0.0377
Schistosoma mansoni ran 0.0021 0.0096 0.0161
Brugia malayi ORL1-like opioid receptor 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0224 0.0291
Onchocerca volvulus Deterin homolog 0.0054 0.043 0.2238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Brugia malayi hypothetical protein 0.0034 0.0224 0.0224
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0118 1
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis somatostatin receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0283 0.2812 0.3652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0824 0.1384
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0224 0.0377
Onchocerca volvulus 0.0034 0.0224 0.1166
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0224 0.0377
Echinococcus multilocularis GPCR, family 2 0.0033 0.0215 0.036
Echinococcus granulosus sex peptide receptor 0.0034 0.0224 0.0377
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0224 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0224 0.0377
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0215 0.036
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0494 0.5
Schistosoma mansoni neuropeptide receptor 0.0034 0.0224 0.0377
Echinococcus granulosus somatostatin receptor 0.0034 0.0224 0.0377
Loa Loa (eye worm) hypothetical protein 0.0071 0.0609 0.0791
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1235 0.1605
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0831 0.1396
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0224 0.0377
Brugia malayi Dopamine receptor protein 1 0.0034 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0291
Schistosoma mansoni histamine h1 receptor 0.0034 0.0224 0.0377
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0096 0.0096

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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