pI: 8.4034 |
Length (AA): 1125 |
MW (Da): 125508 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 272 | 1u5q (A) | 48 | 315 | 53.00 | 0 | 1 | 0.929289 | -1.07 |
4 | 357 | 6b1u (A) | 38 | 423 | 19.00 | 0 | 1 | 0.423467 | 0.33 |
609 | 996 | 5lm2 (B) | 9 | 338 | 17.00 | 0 | 0.89 | 0.196689 | 0.65 |
741 | 969 | 4tql (A) | 9 | 237 | 23.00 | 0.012 | 0.42 | 0.422956 | -0.46 |
746 | 978 | 2yfa (A) | 48 | 274 | 9.00 | 0 | 0.2 | 0.273911 | -1.05 |
887 | 993 | 2fxm (B) | 860 | 956 | 37.00 | 0.0039 | 0.11 | 0.260511 | 0.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129521)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_55590 | Serine/threonine-protein kinase SULU |
Brugia malayi | Bm1_57415 | hypothetical protein |
Caenorhabditis elegans | CELE_T17E9.1 | Protein KIN-18, isoform A |
Drosophila melanogaster | Dmel_CG14217 | CG14217 gene product from transcript CG14217-RF |
Echinococcus granulosus | EgrG_001094600 | serine:threonine protein kinase TAO1 |
Echinococcus multilocularis | EmuJ_001094600 | serine:threonine protein kinase TAO1 |
Homo sapiens | ENSG00000149930 | TAO kinase 2 |
Homo sapiens | ENSG00000135090 | TAO kinase 3 |
Homo sapiens | ENSG00000160551 | TAO kinase 1 |
Loa Loa (eye worm) | LOAG_02983 | STE/STE20/TAO protein kinase |
Mus musculus | ENSMUSG00000059981 | TAO kinase 2 |
Mus musculus | ENSMUSG00000061288 | TAO kinase 3 |
Mus musculus | ENSMUSG00000017291 | TAO kinase 1 |
Schistosoma japonicum | Sjp_0069910 | ko:K04429 thousand and one amino acid protein kinase, putative |
Schistosoma mansoni | Smp_068060.1 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.027126.00 | |
Schmidtea mediterranea | mk4.004610.05 | Serine/threonine-protein kinase SULU |
Schmidtea mediterranea | mk4.008936.01 | |
Schmidtea mediterranea | mk4.023185.00 | |
Schmidtea mediterranea | mk4.024895.00 | Serine/threonine-protein kinase SULU |
Schmidtea mediterranea | mk4.005348.00 | |
Schmidtea mediterranea | mk4.005765.00 | Serine/threonine-protein kinase TAO2 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T17E9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T17E9.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T17E9.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T17E9.1 | Caenorhabditis elegans | sterile | wormbase |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | TAO kinase 3 | Compounds | References |
Homo sapiens | TAO kinase 1 | Compounds | References |
Homo sapiens | TAO kinase 2 | Compounds | References |
Caenorhabditis elegans | Protein KIN-18, isoform A | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Patiria pectinifera | Cdc2 | 300 aa | 24.3% | 284 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 24.5% | 237 aa | Compounds | References |