Detailed information for compound 171278

Basic information

Technical information
  • TDR Targets ID: 171278
  • Name: azanium
  • MW: 18.0385 | Formula: H4N+
  • H donors: 1 H acceptors: 0 LogP: -0.73 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH4+]
  • InChi: 1S/H3N/h1H3/p+1
  • InChiKey: QGZKDVFQNNGYKY-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • ammonium
  • azane; hydron
  • ammonia; hydron
  • Quaternary Ammonium Compounds
  • ammonium hydroxide
  • nitrogen(+1) dihydride cation
  • 14798-03-9
  • 6684-80-6
  • 14158-23-7
  • [NH4](+)
  • AMMONIUM CATION WITH D
  • ND4
  • AIDS-114551
  • AIDS114551
  • Ammonium ion(+)
  • Ammonium(+)
  • NH4+
  • Ammonium ion
  • Ammonium(1+)
  • CHEBI:29338
  • NH2(+)
  • azanylium
  • dihydridonitrogen(1+)
  • CHEBI:29352
  • N(+)
  • Nitrogen cation
  • nitrogen(1+)
  • Ammonium ion(1+)
  • C01342
  • NH2+
  • Ammonia ion (NH4+)
  • Ammonia, ion (NH41+)
  • Ammonium (8CI,9CI)
  • Ammonium (NH4+)
  • Ammonium cation
  • Ammonium ion (NH4+)
  • Nitrogen tetrahydride
  • CHEBI:28938
  • NH4(+)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) Curated by TDR Targets References
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) Curated by TDR Targets References
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium berghei glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium falciparum glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium vivax glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase GlnA1 Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum ko:K01915 glutamine synthetase [EC6.3.1.2], putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Neospora caninum Glutamine synthetase (EC 6.3.1.2), related Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium leprae GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Toxoplasma gondii glutamine synthetase, type I, putative Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium parvum glutamate synthetase, possible bacterial origin, beta-grasp+glutamate synthase catalytic domain Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum expressed protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium hominis glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum Glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Wolbachia endosymbiont of Brugia malayi glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium knowlesi glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium yoelii glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Trichomonas vaginalis AGC family protein kinase 0.038 0.0439 0.0114
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.105 0.24 0.24
Brugia malayi p70 ribosomal S6 kinase beta 0.105 0.24 0.2051
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Leishmania major protein kinase, putative 0.3648 1 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.067 0.1289 0.1289
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.038 0.0439 0.0439
Echinococcus granulosus aurora kinase A 0.3648 1 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.038 0.0439 0.0439
Loa Loa (eye worm) AGC/NDR protein kinase 0.038 0.0439 0.0439
Echinococcus multilocularis serine:threonine protein kinase N2 0.038 0.0439 0.0439
Entamoeba histolytica protein kinase, putative 0.105 0.24 0.2051
Trichomonas vaginalis AGC family protein kinase 0.3648 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0708 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine kinase 0.038 0.0439 0.0439
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.3648 1 1
Trichomonas vaginalis AGC family protein kinase 0.3648 1 1
Loa Loa (eye worm) AUR protein kinase 0.3648 1 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.3648 1 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0708 0.14 0.0744
Entamoeba histolytica protein kinase, putative 0.105 0.24 0.2051
Loa Loa (eye worm) AUR protein kinase 0.3648 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0708 0.14 0.14
Brugia malayi Protein kinase domain containing protein 0.105 0.24 0.2051
Trichomonas vaginalis AGC family protein kinase 0.038 0.0439 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Echinococcus granulosus nervana 2 0.067 0.1289 0.1289
Echinococcus multilocularis aurora kinase A 0.3648 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.067 0.1289 0.1289
Toxoplasma gondii aurora kinase 0.3648 1 1
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0472 0.0708 1
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Schistosoma mansoni glutamine synthetase bacteria 0.0364 0.0393 0.0393
Echinococcus granulosus protein kinase c epsilon type 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine-protein kinase 0.0708 0.14 0.14
Echinococcus multilocularis Protein kinase C, brain isozyme 0.038 0.0439 0.0439
Loa Loa (eye worm) AGC/PKN protein kinase 0.038 0.0439 0.0439
Toxoplasma gondii AGC kinase 0.105 0.24 0.182
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Echinococcus multilocularis nervana 2 0.067 0.1289 0.1289
Entamoeba histolytica protein kinase, putative 0.3648 1 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.067 0.1289 0.1289
Plasmodium vivax serine/threonine protein kinase 6, putative 0.3648 1 1
Loa Loa (eye worm) AUR protein kinase 0.3648 1 1
Entamoeba histolytica protein kinase, putative 0.3648 1 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.038 0.0439 0.0439
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0708 0.14 0.0744
Trichomonas vaginalis AGC family protein kinase 0.038 0.0439 0.0114
Echinococcus multilocularis nervana 2 0.067 0.1289 0.1289
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Loa Loa (eye worm) AGC/AKT protein kinase 0.105 0.24 0.24
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0364 0.0393 0.5305
Trichomonas vaginalis AGC family protein kinase 0.3648 1 1
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Entamoeba histolytica PH domain containing protein kinase, putative 0.0708 0.14 0.1005
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.3648 1 1
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.038 0.0439 0.0439
Brugia malayi serine/threonine-protein kinase 6 0.3648 1 1
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Echinococcus granulosus NDR protein kinase 0.038 0.0439 0.0439
Echinococcus multilocularis Glutaredoxin protein 5 0.067 0.1289 0.1289
Entamoeba histolytica protein kinase 2, putative 0.0708 0.14 0.1005
Echinococcus multilocularis protein kinase c iota type 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.3648 1 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0472 0.0708 1
Mycobacterium ulcerans glutamine synthetase 0.0472 0.0708 1
Trypanosoma brucei aurora B kinase 0.3648 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.105 0.24 0.24
Echinococcus granulosus nervana 2 0.067 0.1289 0.1289
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0708 0.14 0.14
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0708 0.14 0.14
Entamoeba histolytica PH domain containing protein kinase, putative 0.0708 0.14 0.1005
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.038 0.0439 0.0439
Trichomonas vaginalis AGC family protein kinase 0.3648 1 1
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Entamoeba histolytica protein kinase domain containing protein 0.3648 1 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.3648 1 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.038 0.0439 0.0439
Echinococcus granulosus Protein kinase C brain isozyme 0.038 0.0439 0.0439
Onchocerca volvulus Glutamine synthetase homolog 0.023 0 0.5
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0472 0.0708 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.038 0.0439 0.0439
Entamoeba histolytica protein kinase, putative 0.105 0.24 0.2051
Echinococcus multilocularis rac serine:threonine kinase 0.0708 0.14 0.14
Echinococcus multilocularis serine:threonine protein kinase 38 0.038 0.0439 0.0439
Echinococcus multilocularis serine threonine protein kinase 0.038 0.0439 0.0439
Echinococcus multilocularis protein kinase c epsilon type 0.038 0.0439 0.0439
Entamoeba histolytica protein kinase , putative 0.3648 1 1
Schistosoma mansoni atypical protein kinase C 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.038 0.0439 0.0439
Echinococcus granulosus protein kinase C gamma type 0.038 0.0439 0.0439
Echinococcus granulosus protein kinase c iota type 0.038 0.0439 0.0439
Trypanosoma cruzi aurora B kinase, putative 0.3648 1 1
Trypanosoma cruzi Protein kinase B 0.0708 0.14 0.14
Echinococcus granulosus serine:threonine protein kinase N2 0.038 0.0439 0.0439
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0364 0.0393 0.5
Plasmodium falciparum serine/threonine protein kinase, putative 0.3648 1 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0708 0.14 0.14
Giardia lamblia Aurora kinase 0.3648 1 1
Schistosoma mansoni glutamine synthetase bacteria 0.0364 0.0393 0.0393
Echinococcus granulosus serine:threonine protein kinase 12 B 0.3648 1 1
Trichomonas vaginalis AGC family protein kinase 0.105 0.24 0.2142
Echinococcus multilocularis serine:threonine protein kinase N2 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine-protein kinase 0.0708 0.14 0.14
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.038 0.0439 0.0439
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.038 0.0439 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.038 0.0439 0.0439
Schistosoma mansoni protein kinase 0.3648 1 1
Brugia malayi serine/threonine kinase 12 0.3648 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0708 0.14 0.14
Trichomonas vaginalis AGC family protein kinase 0.038 0.0439 0.0114

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) 0 nM Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand; Not determined ChEMBL. 10447950
Ki (binding) 0 nM Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand; Not determined ChEMBL. 10447950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 256476  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 6144381
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 256476  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12540549 16973920 7937767
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 6149  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 6144381
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 6150  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 6144381
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6149  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12540549 16973920 7937767
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6150  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12540549 16973920 7937767

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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