Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0216 | 0.01 | 0.01 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0216 | 0.01 | 0.01 |
Echinococcus granulosus | protein kinase | 0.0517 | 0.2752 | 0.2752 |
Schistosoma mansoni | glutaminase | 0.033 | 0.1105 | 0.1105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.0124 | 0.0124 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0216 | 0.01 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.1105 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0219 | 0.0124 | 0.0024 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0731 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.1105 | 0.1015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.0124 | 0.0124 |
Echinococcus multilocularis | 0.0517 | 0.2752 | 0.2752 | |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0216 | 0.01 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0219 | 0.0124 | 0.0124 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0216 | 0.01 | 0.01 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0216 | 0.01 | 0.01 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.134 | 1 | 1 |
Schistosoma mansoni | vam6/vps39 related | 0.0216 | 0.01 | 0.01 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0219 | 0.0124 | 0.0124 |
Schistosoma mansoni | protein kinase | 0.0219 | 0.0124 | 0.0124 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0219 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0219 | 0.0124 | 0.0024 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0216 | 0.01 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.01 | 0.01 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.134 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0219 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0517 | 0.2752 | 0.2678 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0216 | 0.01 | 0.01 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0219 | 0.0124 | 0.0124 |
Schistosoma mansoni | protein kinase | 0.0733 | 0.4654 | 0.4654 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0216 | 0.01 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.1105 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0219 | 0.0124 | 0.0124 |
Onchocerca volvulus | 0.0216 | 0.01 | 0.5 | |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.1105 | 0.1015 |
Schistosoma mansoni | protein kinase | 0.0517 | 0.2752 | 0.2752 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.1105 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0731 | 0.4631 | 0.4577 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.134 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.134 | 1 | 1 |
Brugia malayi | probable protein kinase | 0.0733 | 0.4654 | 0.46 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.