Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcriptional regulator | 0.0135 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 1 | 1 |
Leishmania major | silent information regulator 2, putative | 0.0135 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0135 | 1 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0135 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0135 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 1 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 1 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 1 | 0.5 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0135 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 1 | 1 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0135 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 0.5126 | 1 | |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.