Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 2 (neuronal) | References | |
Homo sapiens | cholinergic receptor, nicotinic, alpha 3 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 4 (neuronal) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 4 (neuronal) | 498 aa | 508 aa | 31.1 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 505 aa | 486 aa | 34.6 % |
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 2 (neuronal) | 502 aa | 482 aa | 32.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.4335 | 0.2889 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0221 | 0.8296 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.4335 | 0.2889 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0221 | 0.8296 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0246 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0221 | 0.8296 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0161 | 0.4335 | 0.5226 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0221 | 0.8296 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0161 | 0.4335 | 0.5226 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0221 | 0.8296 | 0.6992 |
Schistosoma mansoni | glycogen phosphorylase | 0.0221 | 0.8296 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0095 | 0 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0221 | 0.8296 | 0.6992 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0221 | 0.8296 | 0.7861 |
Giardia lamblia | Glycogen phosphorylase | 0.0221 | 0.8296 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0221 | 0.8296 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0095 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0246 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0221 | 0.8296 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0246 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0246 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.4 nM | Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells | ChEMBL. | 23025891 |
Ki (binding) | = 23 nM | Displacement of [3H]epibatidine from human alpha7 nAChR expressed in human HEK/RIC3 cells | ChEMBL. | 23025891 |
Ki (binding) | = 27 nM | Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells | ChEMBL. | 23025891 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.