Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.2379 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0019 | 0.0041 | 0.0041 |
Schistosoma mansoni | cell adhesion molecule | 0.0019 | 0.0041 | 0.0041 |
Schistosoma mansoni | nephrin | 0.0019 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.2379 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0019 | 0.0041 | 0.0041 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.2379 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | twitchin | 0.0025 | 0.0066 | 0.0066 |
Echinococcus multilocularis | Immunoglobulin | 0.0019 | 0.0041 | 0.0041 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.067 | 0.2787 | 0.2787 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0041 | 0.0001 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0022 | 0.0053 | 0.0013 |
Trypanosoma brucei | protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0019 | 0.0041 | 0.0041 |
Schistosoma mansoni | vesicular amine transporter | 0.0019 | 0.0041 | 0.0041 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0019 | 0.0041 | 0.0041 |
Echinococcus multilocularis | Immunoglobulin | 0.0019 | 0.0041 | 0.0041 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0019 | 0.0041 | 0.0041 |
Leishmania major | protein kinase, putative | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2379 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0022 | 0.0053 | 0.0013 |
Plasmodium falciparum | protein kinase, putative | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0019 | 0.0041 | 0.0041 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0019 | 0.0041 | 0.0041 |
Echinococcus granulosus | defective proboscis extension response | 0.0019 | 0.0041 | 0.0041 |
Echinococcus granulosus | roundabout 2 | 0.0019 | 0.0041 | 0.0041 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0019 | 0.0041 | 0.0041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.3 % | Binding affinity to TRKA at 10 uM by high throughput binding assay relative to control | ChEMBL. | 22575050 |
Activity (binding) | = 100 % | Binding affinity to PI3Kalpha at 10 uM by high throughput binding assay relative to control | ChEMBL. | 22575050 |
Kd (binding) | = 88 nM | Binding affinity to TRKA by high throughput assay | ChEMBL. | 22575050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.