Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Cell division protein ftsZ | Starlite/ChEMBL | References |
Escherichia coli | GTP-binding tubulin-like cell division protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cell division protein ftsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Treponema pallidum | cell division protein FtsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Mycobacterium tuberculosis | Cell division protein FtsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Brugia malayi | Cell division protein ftsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Mycobacterium ulcerans | cell division protein FtsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Mycobacterium leprae | cell division protein FtsZ | Get druggable targets OG5_128807 | All targets in OG5_128807 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0339 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0731 | 1 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.0361 | 0.0571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 0 | 0.5 |
Treponema pallidum | cell division protein FtsZ | 0.0731 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 0 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.0351 | 0.0314 | 0.5507 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0731 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0339 | 0 | 0.5 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0731 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0339 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Effect on MAP-rich pig beta-tubulin polymerization at 40 ug/mL by microtiter plate-based light scattering assay | ChEMBL. | 23050700 | |
Activity (binding) | Stimulation of Escherichia coli FtsZ assembly at 20 ug/mL by transmission electron microscopy | ChEMBL. | 23050700 | |
Activity (binding) | Binding affinity to Escherichia coli FtsZ at 40 uM by fluorescence anisotropy BoGTPgammaS competition assay | ChEMBL. | 23050700 | |
Activity (binding) | Stimulation of Staphylococcus aureus FtsZ self-polymerization by microtiter plate-based light scattering assay | ChEMBL. | 23050700 | |
Activity (binding) | Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli BL21 (DE3) at 40 uM by fluorescence anisotropy BoGTPgammaS competition assay | ChEMBL. | 23050700 | |
Activity (binding) | Stimulation of Staphylococcus aureus FtsZ assembly and bundling at 20 ug/mL by transmission electron microscopy | ChEMBL. | 23050700 | |
Activity (binding) | Stimulation of Escherichia coli FtsZ self-polymerization by microtiter plate-based light scattering assay | ChEMBL. | 23050700 | |
Kd (binding) | = 3.5 uM | Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli BL21 (DE3) at 25 degC by fluorescence anisotropy assay | ChEMBL. | 23050700 |
Kd (binding) | = 3.8 uM | Binding affinity to Escherichia coli FtsZ at 25 degC by fluorescence anisotropy assay | ChEMBL. | 23050700 |
MBC (functional) | = 16 ug ml-1 | Antimicrobial activity against Escherichia coli W4573 incubated for 24 hrs in broth followed by colony transfer to tryptic soy agar for further 24 hrs incubation | ChEMBL. | 23050700 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.