Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 0.3 | Relative binding affinity for androgen receptor of prostate of rat at 2 hr | ChEMBL. | 2897467 |
RBA (binding) | = 2.5 | Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 0.3 | Relative binding affinity for androgen receptor of prostate of rat at 2 hr | ChEMBL. | 2897467 |
RBA (binding) | = 2.5 | Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 8.4 | Relative binding affinity to glucocorticoid receptor on cytosol from liver at 4 hr | ChEMBL. | 2897467 |
RBA (binding) | = 24 | Relative binding affinity to glucocorticoid receptor on cytosol from liver at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 40 | Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 67 | Relative binding affinity for progestin receptor of uterus of rabbit at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 85 | Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 4 hr | ChEMBL. | 2897467 |
RBA (binding) | = 95 | Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 24 hr | ChEMBL. | 2897467 |
RBA (binding) | = 140 | Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 4 hr | ChEMBL. | 2897467 |
Relative activity (functional) | = 110 % | Glucocorticoid induced Tyrosine Aminotransferase activity relative to dexamethasone | ChEMBL. | 2897467 |
Relative activity (functional) | = 110 % | Glucocorticoid induced Tyrosine Aminotransferase activity relative to dexamethasone | ChEMBL. | 2897467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.