Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.006 uM | Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V2 receptor | ChEMBL. | 12372506 |
IC50 (binding) | = 0.006 uM | Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V2 receptor | ChEMBL. | 12372506 |
IC50 (binding) | ~ 0.1 uM | Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V1a receptor | ChEMBL. | 12372506 |
IC50 (binding) | ~ 0.1 uM | Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V1a receptor | ChEMBL. | 12372506 |
Ki (binding) | uM | Inhibition of AVP mediated activation of human vasopressin V2 receptor expressed in HEK-293 cells | ChEMBL. | 12372506 |
Ki (binding) | uM | Inhibition of AVP mediated activation of human vasopressin V1a receptor expressed in HEK-293 cells | ChEMBL. | 12372506 |
Ki (binding) | 0 uM | Inhibition of AVP mediated activation of human vasopressin V2 receptor expressed in HEK-293 cells | ChEMBL. | 12372506 |
Ki (binding) | 0 uM | Inhibition of AVP mediated activation of human vasopressin V1a receptor expressed in HEK-293 cells | ChEMBL. | 12372506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.