Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | scavenger receptor class B, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0153 | 0.0459 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0153 | 0.0459 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0153 | 0.0459 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0153 | 0.0459 | 0.0459 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0153 | 0.0459 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0153 | 0.0459 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0153 | 0.0459 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0153 | 0.0459 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0153 | 0.0459 | 0.5 |
Onchocerca volvulus | 0.0153 | 0.0459 | 0.0459 | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0153 | 0.0459 | 0.0459 |
Echinococcus granulosus | aminopeptidase N | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0153 | 0.0459 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.602 | 0.6999 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.8601 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0153 | 0.0459 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | aminopeptidase N | 0.0153 | 0.0459 | 0.0533 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0153 | 0.0459 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.042 | 0.7419 | 0.8626 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0153 | 0.0459 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0519 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0153 | 0.0459 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0153 | 0.0459 | 0.5 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0459 | 0.0459 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0459 | 0.0459 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 nM | Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human HuH7.5 cells by luciferase reporter gene assay | ChEMBL. | 22784640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.