Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | pteridine reductase 1 | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | pteridine reductase 1 | 288 aa | 281 aa | 25.3 % |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aminopeptidase, putative | 0.0121 | 0.1279 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0121 | 0.1279 | 0.2601 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0036 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0208 | 0.3904 | 0.301 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0121 | 0.1279 | 0.2601 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.3904 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0121 | 0.1279 | 0.1279 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.3904 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0121 | 0.1279 | 0.3276 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.3904 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0238 | 0.4816 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0121 | 0.1279 | 0.2653 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0121 | 0.1279 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0121 | 0.1279 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.3904 | 0.4477 |
Echinococcus multilocularis | aminopeptidase N | 0.041 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0235 | 0.4722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.6362 | 0.7295 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.8721 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.3904 | 0.301 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0036 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.0121 | 0.1279 | 0.1467 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.3904 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.3904 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.3904 | 0.3904 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0121 | 0.1279 | 0.1279 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.3904 | 0.301 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0121 | 0.1279 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0121 | 0.1279 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0331 | 0.7641 | 0.8762 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0121 | 0.1279 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0121 | 0.1279 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0121 | 0.1279 | 0.1279 |
Onchocerca volvulus | 0.041 | 1 | 1 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.0036 | 0.028 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.0036 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0121 | 0.1279 | 0.1279 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0121 | 0.1279 | 0.2653 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0121 | 0.1279 | 0.2653 |
Echinococcus granulosus | aminopeptidase N | 0.041 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0121 | 0.1279 | 0.1279 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0121 | 0.1279 | 0.3276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 27.4 % | Inhibition of pteridine reductase in Leishmania major promastigotes assessed as increase in pyrimethamine-induced growth inhibition by measuring parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
Activity (functional) | = 100.1 % | Antiparasitic activity against Leishmania mexicana promastigotes assessed as parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
Activity (functional) | = 122.2 % | Antiparasitic activity against Leishmania major promastigotes assessed as parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
Ki (binding) | = 30 nM | Inhibition of Leishmania major PTR1 by spectrophotometric assay | ChEMBL. | 22946585 |
Ki (binding) | = 4330 nM | Inhibition of human DHFR by spectrophotometric analysis | ChEMBL. | 22946585 |
Ki (binding) | = 64000 nM | Inhibition of human TS by spectrophotometric analysis | ChEMBL. | 22946585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.