Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.109 | 0.8721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.6362 | 0.7295 |
Echinococcus granulosus | aminopeptidase N | 0.1216 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0358 | 0.1279 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0358 | 0.1279 | 0.1279 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0358 | 0.1279 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0358 | 0.1279 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0358 | 0.1279 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0358 | 0.1279 | 0.1279 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0358 | 0.1279 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0358 | 0.1279 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0358 | 0.1279 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0358 | 0.1279 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0984 | 0.7641 | 0.8762 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0358 | 0.1279 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0358 | 0.1279 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0358 | 0.1279 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0358 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | aminopeptidase N | 0.0358 | 0.1279 | 0.1467 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0358 | 0.1279 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0358 | 0.1279 | 0.1279 |
Onchocerca volvulus | 0.1216 | 1 | 1 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0358 | 0.1279 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0358 | 0.1279 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0358 | 0.1279 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0358 | 0.1279 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.1216 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.7 uM | Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.