Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0146 | 1 | 1 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.0048 | 0.1996 | 0.0695 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.0048 | 0.1996 | 0.0695 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0146 | 1 | 1 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.0048 | 0.1996 | 0.0695 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.2969 | 0.1826 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0048 | 0.1996 | 0.1996 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.0146 | 1 | 1 |
Brugia malayi | DNA polymerase family B containing protein | 0.0048 | 0.1996 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1996 | 0.1797 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.1398 | 0.1398 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.2046 | 0.1849 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.2969 | 0.1826 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0146 | 1 | 1 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.0048 | 0.1996 | 0.1996 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.0048 | 0.1996 | 0.1797 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.2593 | 0.2593 |
Toxoplasma gondii | DNA polymerase | 0.0146 | 1 | 1 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0048 | 0.1996 | 0.0695 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0146 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0048 | 0.1996 | 0.1797 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.2046 | 0.2046 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.0048 | 0.1996 | 0.0695 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.0048 | 0.1996 | 0.1996 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.1671 | 0.1671 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0146 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0048 | 0.1996 | 0.1797 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0048 | 0.1996 | 0.1996 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0048 | 0.1996 | 0.0695 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0146 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0048 | 0.1996 | 0.1797 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0146 | 1 | 1 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0146 | 1 | 1 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0146 | 1 | 1 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.0048 | 0.1996 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2969 | 0.2794 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.0146 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.012 | 0.7812 | 0.7266 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0146 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 10000 nM | Positive allosteric modulation of human mGluR5 expressed in recombinant HEK293 cells by FLIPR assay | ChEMBL. | 22975301 |
Emax (binding) | = -7 % | Positive allosteric modulation of human mGluR5 expressed in recombinant HEK293 cells by FLIPR assay | ChEMBL. | 22975301 |
IC50 (binding) | = 2500 nM | Negative allosteric modulation of human mGluR5 expressed in recombinant HEK293 cells by FLIPR assay | ChEMBL. | 22975301 |
Inhibition (binding) | = 70 % | Negative allosteric modulation of human mGluR5 expressed in recombinant HEK293 cells by FLIPR assay | ChEMBL. | 22975301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.