Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 7 (herpes virus-associated) | Starlite/ChEMBL | References |
Homo sapiens | ubiquitin specific peptidase 47 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.5 uM | Inhibition of USP47 by Ub-CHOP reporter assay | ChEMBL. | 24900381 |
IC50 (binding) | = 7.8 uM | Inhibition of recombinant USP7 expressed in Sf9 cells by Ub-CHOP reporter assay | ChEMBL. | 24900381 |
Inhibition (binding) | Inhibition of caspase 3 using DEVD-Rh110 as substrate incubated for 30 mins prior to substrate addition by fluorimetric analysis | ChEMBL. | 24900381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.