Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0218 | 0.4044 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0369 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.4044 | 0.7391 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 0.7391 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0218 | 0.4044 | 0.7391 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0218 | 0.4044 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0218 | 0.4044 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | FTZ F1 alpha | 0.0218 | 0.4044 | 0.7391 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.4044 | 0.7391 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0218 | 0.4044 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0218 | 0.4044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0218 | 0.4044 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | 0.0218 | 0.4044 | 0.5 | |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0218 | 0.4044 | 0.7391 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 0.7391 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0218 | 0.4044 | 0.7391 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0254 | 0.5471 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.4044 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0218 | 0.4044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | nuclear hormone receptor | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.4044 | 0.7391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 250 nM | Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins prior to IL6-induction measured after 30 to 45 mins | ChEMBL. | 22698084 |
EC50 (binding) | = 2300 nM | Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins prior to EPO-induction measured after 30 to 45 mins | ChEMBL. | 22698084 |
Ki (binding) | = 6.7 nM | Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins | ChEMBL. | 22698084 |
Ki (binding) | = 18 nM | Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins | ChEMBL. | 22698084 |
T1/2 (ADMET) | > 8 hr | Half life in human hepatocytes at 1 uM by LC/MS/MS analysis | ChEMBL. | 22698084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.