Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | receptor type tyrosine protein phosphatase | protein tyrosine phosphatase, non-receptor type 7 | 434 aa | 400 aa | 24.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0075 | 0.2768 | 0.2768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0127 | 0.9857 | 0.9857 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0129 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0129 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0075 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0129 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0075 | 0.2768 | 0.2808 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0075 | 0.2768 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0129 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0129 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0075 | 0.2768 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0129 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.9857 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0075 | 0.2768 | 0.2808 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0075 | 0.2768 | 0.2768 |
Schistosoma mansoni | protein kinase | 0.0129 | 1 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0075 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0129 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0129 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0129 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0129 | 1 | 0.5 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0129 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0129 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0129 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0129 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 uM | Inhibition of HePTP expressed in Escherichia coli BL21 using pNPP substrate | ChEMBL. | 21341673 |
IC50 (binding) | = 22 uM | Inhibition of LYP expressed in Escherichia coli BL21 using pNPP substrate | ChEMBL. | 21341673 |
IC50 (binding) | > 40 uM | Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrate | ChEMBL. | 21341673 |
IC50 (binding) | > 80 uM | Inhibition of LYP expressed in Escherichia coli BL21 using ARLIED-NEpYTAREG substrate | ChEMBL. | 21341673 |
IC50 (binding) | > 90 uM | Inhibition of LMPTP-A expressed in Escherichia coli BL21 using pNPP substrate | ChEMBL. | 21341673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.