Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 47 | Starlite/ChEMBL | References |
Homo sapiens | ubiquitin specific peptidase 7 (herpes virus-associated) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0026 | 0.0241 | 0.1728 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.1879 | 0.2143 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0026 | 0.0241 | 0.1728 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1507 | 0.1719 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.4373 | 0.4373 |
Trypanosoma cruzi | ubiquitin hydrolase, putative | 0.0024 | 0.0164 | 0.0164 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0058 | 0.1394 | 0.1394 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0058 | 0.1402 | 0.1599 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0058 | 0.1394 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.1879 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.006 | 0.0433 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0819 | 0.0819 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4373 | 0.4373 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.104 | 0.5 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 7 | 0.0038 | 0.0659 | 0.3508 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0819 | 0.0819 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 7 | 0.0038 | 0.0659 | 0.3508 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.1879 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0651 | 0.4669 |
Loa Loa (eye worm) | fli-1 protein | 0.0218 | 0.7094 | 0.8092 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1148 | 0.1148 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0026 | 0.0241 | 0.1728 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 7 | 0.0058 | 0.1402 | 0.7463 |
Plasmodium vivax | ubiquitin carboxyl-terminal hydrolase family 2, putative | 0.0039 | 0.0728 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 7 | 0.0058 | 0.1402 | 0.7463 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0819 | 0.0819 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1879 | 0.2143 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.4944 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 7 (C19 family) | 0.0058 | 0.1402 | 0.1977 |
Loa Loa (eye worm) | ubiquitin carboxyl-terminal hydrolase | 0.0058 | 0.1402 | 0.1599 |
Loa Loa (eye worm) | ubiquitin carboxyl-terminal hydrolase | 0.0264 | 0.8767 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0819 | 0.0819 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0264 | 0.8767 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1879 | 0.2143 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0024 | 0.0164 | 0.0164 |
Schistosoma mansoni | ets-related | 0.0218 | 0.7094 | 1 |
Brugia malayi | Fli-1 protein | 0.0218 | 0.7094 | 0.8092 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.8586 | 0.9794 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.4944 | 1 |
Trypanosoma cruzi | ubiquitin hydrolase, putative | 0.0058 | 0.1394 | 0.1394 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4373 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0548 | 0.0625 |
Trichomonas vaginalis | ubiquitin specific protease, putative | 0.0024 | 0.0164 | 0.1174 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0058 | 0.1394 | 0.1394 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0651 | 0.4669 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.1879 | 0.2649 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0651 | 0.4669 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 4.2 uM | Inhibition of USP7 (unknown origin) by Ub-CHOP reporter assay | ChEMBL. | 25364867 |
IC50 (binding) | = 8 uM | Inhibition of recombinant USP7 expressed in Sf9 cells by Ub-CHOP reporter assay | ChEMBL. | 24900381 |
IC50 (binding) | = 8.7 uM | Inhibition of USP47 by Ub-CHOP reporter assay | ChEMBL. | 24900381 |
Inhibition (binding) | Inhibition of caspase 3 using DEVD-Rh110 as substrate incubated for 30 mins prior to substrate addition by fluorimetric analysis | ChEMBL. | 24900381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.