Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic kainate 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0347 | 0.6295 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0394 | 0.7613 | 0.7613 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0197 | 0.2093 | 0.2093 |
Echinococcus granulosus | glutamate receptor 1 | 0.0255 | 0.3715 | 0.3715 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0247 | 0.3496 | 0.4003 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3715 | 0.292 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0436 | 0.8776 | 0.8776 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.034 | 0.6102 | 0.6102 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0436 | 0.8776 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.0347 | 0.6295 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0436 | 0.8776 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0247 | 0.3496 | 0.3496 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.6295 | 1 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0255 | 0.3715 | 0.3715 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.016 | 0.1048 | 0.1048 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3715 | 0.292 |
Echinococcus granulosus | glutamate receptor 4 | 0.0255 | 0.3715 | 0.3715 |
Schistosoma mansoni | glutamate receptor kainate | 0.0218 | 0.2674 | 0.224 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0347 | 0.6295 | 0.6295 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0262 | 0.3898 | 0.3898 |
Schistosoma mansoni | glutamate receptor kainate | 0.0218 | 0.2674 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3715 | 0.292 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0436 | 0.8776 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0394 | 0.7613 | 0.7613 |
Echinococcus granulosus | nmda type glutamate receptor | 0.016 | 0.1048 | 0.1048 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0247 | 0.3496 | 0.3496 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0347 | 0.6295 | 0.5 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.034 | 0.6102 | 0.6102 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0224 | 0.2852 | 0.2623 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 137 nM | Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay | ChEMBL. | 23092360 |
IC50 (functional) | = 164 nM | Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay | ChEMBL. | 23092360 |
IC50 (functional) | = 5406 nM | Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay | ChEMBL. | 23092360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.