Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Onchocerca volvulus | 0.0035 | 0.1001 | 1 | |
Trichomonas vaginalis | protein phosphatase type 2C, putative | 0.0113 | 0.6683 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.8449 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.275 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.8449 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.275 | 0.3255 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8449 | 0.8449 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.236 | 0.2793 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.1001 | 0.1185 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.6672 | 0.6672 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.1001 | 0.1001 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.2513 | 0.2974 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.0143 | 0.0169 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.275 | 0.3255 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.0143 | 0.0169 |
Trichomonas vaginalis | protein phosphatase 2C, putative | 0.0113 | 0.6683 | 1 |
Onchocerca volvulus | 0.0023 | 0.0143 | 0.143 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.275 | 1 |
Onchocerca volvulus | 0.0023 | 0.0143 | 0.143 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.8449 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.0143 | 0.0169 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.236 | 0.2793 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.8449 | 0.8449 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.275 | 0.3255 |
Schistosoma mansoni | gliotactin | 0.0023 | 0.0143 | 0.0169 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.2513 | 0.2513 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.8449 | 0.8449 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0143 | 0.0143 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0147 | 0.9106 | 0.9106 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.0143 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.8449 | 1 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.0143 | 0.0169 |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.0143 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.2239 | 0.2239 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.0143 | 0.0169 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.8449 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.275 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.2513 | 0.9137 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.2513 | 0.2974 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0143 | 0.0143 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.2513 | 0.909 |
Onchocerca volvulus | 0.0023 | 0.0143 | 0.143 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.236 | 0.2793 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.8449 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.8449 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0147 | 0.9106 | 0.9106 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.275 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.2513 | 0.2974 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.1001 | 0.3293 |
Onchocerca volvulus | 0.0023 | 0.0143 | 0.143 | |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.1001 | 0.1185 |
Schistosoma mansoni | single-minded | 0.0047 | 0.1896 | 0.2244 |
Entamoeba histolytica | leucine rich repeat / protein phosphatase 2C domain containing protein | 0.0113 | 0.6683 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.2513 | 0.909 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.8449 | 0.8449 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.275 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.275 | 0.3255 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.8449 | 0.8449 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.2513 | 0.909 |
Onchocerca volvulus | 0.0023 | 0.0143 | 0.143 | |
Trichomonas vaginalis | protein phosphatase 2C delta isoform, putative | 0.0113 | 0.6683 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8449 | 0.8449 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.0143 | 0.0169 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.1896 | 0.2244 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0143 | 0.0143 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.2 nM | Inhibition of human thrombin using Tos-Gly-Pro-Arg-AMC as substrate after 600 secs by fluorimetric method | ChEMBL. | 22612268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.