Detailed view for Smp_078670

Basic information

TDR Targets ID: 292228
Schistosoma mansoni, family S9 non-peptidase homologue (S09 family)
Source Database / ID:  GeneDB

pI: 6.8949 | Length (AA): 319 | MW (Da): 35663 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00135   Carboxylesterase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004104   cholinesterase activity  

Metabolic Pathways

Glycerophospholipid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
54 317 3be8 (A) 0 300 36.00 0 1 1.19459 -0.13
61 318 6ary (A) 163 407 50.00 0 1 1.41518 -0.68
64 302 5fv4 (A) 7 235 39.00 0 1 1.21122 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136350)

Species Accession Gene Product
Schistosoma japonicum Sjp_0106690   IPR002018,Carboxylesterase, type B,domain-containing
Schistosoma mansoni Smp_078670   family S9 non-peptidase homologue (S09 family)
Schmidtea mediterranea mk4.001099.01   Acetylcholinesterase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Schistosoma haematobium 238361   256710   285588   567174  
Annotator: stewac@u.washington.edu. Comment: 2009/04/02. References: 11821256 14527722
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) 285588   567174  
Annotator: stewac@u.washington.edu. Comment: 2009/04/02. References: 14527722
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Schistosoma mansoni 285588   567174  
Annotator: stewac@u.washington.edu. Comment: 2009/04/02. References: 14527722

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1163 0.597 1
0.1012 0.6006 1
0.0021 0.5 0.5
0.0038 0.5 0.5
0.0021 0.5 0.5
0.007 0.5066 0.7296
0.1125 0.3386 1
0.1 0.471 1
0.0021 0.5 0.5
0.1012 0.6006 1
0.1012 0.6006 1
0.0018 0.5 0.5
0.0053 0.5 0.5
0.1002 0.2649 1
0.1012 0.6006 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_078670 (Schistosoma mansoni), family S9 non-peptidase homologue (S09 family)
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