Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Onchocerca volvulus | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Brugia malayi | protein kinase C II. | 0.0044 | 0.0563 | 1 |
Toxoplasma gondii | AGC kinase | 0.0026 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.9227 | 0.9226 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0026 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.9227 | 0.9226 |
Entamoeba histolytica | protein kinase, putative | 0.0026 | 0.0017 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.9774 | 0.9773 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0044 | 0.0563 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.9227 | 0.9226 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0044 | 0.0563 | 1 |
Onchocerca volvulus | 0.0333 | 0.9227 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0563 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0563 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0044 | 0.0563 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.0563 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0044 | 0.0563 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0026 | 0.0017 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0026 | 0.0017 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0044 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0044 | 0.0563 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0026 | 0.0017 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0044 | 0.0563 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0026 | 0.0017 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0044 | 0.0563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 700 nM | Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP | ChEMBL. | 23398373 |
Ki (binding) | > 1250 nM | Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 15 mins by spectrophotometry in presence of ATP | ChEMBL. | 23398373 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.