Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | NADH oxidase | 0.0021 | 0.0027 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0088 | 0.0091 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0021 | 0.0027 | 0.0314 |
Trypanosoma brucei | polo-like protein kinase | 0.0111 | 0.1041 | 0.1516 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0061 | 0.0475 | 0.067 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0617 | 0.6718 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0088 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0587 | 0.0642 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0047 | 0.0321 | 0.044 |
Echinococcus multilocularis | protein patched | 0.0047 | 0.0321 | 0.0295 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.1041 | 0.1516 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0027 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0242 | 0.0322 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0242 | 0.0322 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0027 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0617 | 0.6718 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0021 | 0.0027 | 0.0314 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0587 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0302 | 0.0411 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0587 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0218 | 0.023 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0061 | 0.0475 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0061 | 0.0475 | 0.0517 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.6718 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0061 | 0.0475 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0587 | 0.0837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0.0441 | 0.0618 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0047 | 0.0321 | 0.0345 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0061 | 0.0475 | 0.0449 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0587 | 0.0837 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0088 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0088 | 0.0091 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0111 | 0.1041 | 0.115 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0218 | 0.0286 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0021 | 0.0027 | 0.1926 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0088 | 0.0091 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0088 | 0.0091 |
Leishmania major | trypanothione reductase | 0.0061 | 0.0475 | 0.067 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.1041 | 0.1516 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0021 | 0.0027 | 0.1926 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0111 | 0.1041 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0242 | 0.162 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0047 | 0.0321 | 0.044 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0012 | 0.0257 |
Brugia malayi | hypothetical protein | 0.004 | 0.0242 | 0.0322 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0088 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0417 | 0.0583 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0417 | 0.0583 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.1041 | 0.1516 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0617 | 0.6718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 0.896 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0061 | 0.0475 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0242 | 0.162 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0218 | 0.0286 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.011 | 0.1029 | 0.1498 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0088 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0021 | 0.0027 | 0.0314 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0417 | 0.0452 |
Giardia lamblia | Kinase, PLK | 0.0111 | 0.1041 | 0.1516 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0021 | 0.0027 | 0.0314 |
Plasmodium vivax | glutathione reductase, putative | 0.0061 | 0.0475 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0021 | 0.0027 | 0.0563 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0617 | 0.6718 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0321 | 0.044 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Plasmodium falciparum | glutathione reductase | 0.0061 | 0.0475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0088 | 0.0084 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0088 | 0.1846 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0302 | 0.0411 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.011 | 0.1029 | 0.1498 |
Schistosoma mansoni | patched 1 | 0.0047 | 0.0321 | 0.044 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1029 | 0.1136 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0617 | 0.6718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0088 | 0.0084 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.011 | 0.1029 | 0.987 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0088 | 0.0091 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0587 | 0.0837 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0617 | 0.6718 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0617 | 0.6718 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0088 | 0.1846 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0617 | 0.6718 | 0.6709 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0617 | 0.6718 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0158 | 0.1561 | 0.1538 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0617 | 0.6718 | 1 |
Brugia malayi | glutathione reductase | 0.0061 | 0.0475 | 0.067 |
Brugia malayi | MAP kinase sur-1 | 0.0617 | 0.6718 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0061 | 0.0475 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0441 | 0.0479 |
Toxoplasma gondii | thioredoxin reductase | 0.0061 | 0.0475 | 0.067 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0242 | 0.0216 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0088 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0617 | 0.6718 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0417 | 0.0452 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0158 | 0.1561 | 0.2293 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0021 | 0.0027 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0321 | 0.0345 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0061 | 0.0475 | 0.0517 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0.0441 | 0.0618 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0021 | 0.0027 | 0.0314 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0088 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.0954 | 0.1385 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0021 | 0.0027 | 0.0563 |
Trypanosoma brucei | protein kinase, putative | 0.0617 | 0.6718 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0111 | 0.1041 | 0.1516 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0587 | 0.0562 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0302 | 0.0411 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0617 | 0.6718 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0088 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0021 | 0.0027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 0.896 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0111 | 0.1041 | 0.1516 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.0954 | 0.0929 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0088 | 1 |
Brugia malayi | CHE-14 protein | 0.0047 | 0.0321 | 0.044 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0587 | 0.0837 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0242 | 0.162 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.6718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0088 | 0.0084 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.011 | 0.1029 | 0.1005 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0088 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0396 | 0.0371 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0.1041 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0617 | 0.6718 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0587 | 0.0837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0021 | 0.0027 | 0.1926 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0021 | 0.0027 | 0.0563 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0617 | 0.6718 | 0.7495 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0111 | 0.1041 | 0.1017 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0061 | 0.0475 | 0.067 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0112 | 0.1048 | 0.1526 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0302 | 0.0411 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0587 | 0.0837 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.6718 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.6718 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0587 | 0.0837 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0242 | 0.162 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0617 | 0.6718 | 0.6709 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0088 | 0.0091 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0111 | 0.1041 | 0.1516 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0242 | 0.0322 |
Schistosoma mansoni | kinase | 0.0059 | 0.0456 | 0.0642 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0587 | 0.0642 |
Trypanosoma brucei | trypanothione reductase | 0.0061 | 0.0475 | 0.067 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0047 | 0.0321 | 0.0295 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0021 | 0.0027 | 0.0314 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.1041 | 0.1516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0587 | 0.0837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.