Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA, U transporter 1 | 0.0087 | 0.1421 | 0.1421 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0178 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0328 | 0.6703 | 0.6703 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0178 | 0.0178 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0051 | 0.0051 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0145 | 0.2695 | 0.5 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0051 | 0.0052 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0178 | 0.0183 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0145 | 0.2695 | 0.2763 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0467 | 0.9753 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.0178 | 0.0178 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0145 | 0.2695 | 0.2763 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0051 | 0.0052 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0051 | 0.0051 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0145 | 0.2695 | 0.2763 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0145 | 0.2695 | 0.2763 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0328 | 0.6703 | 0.6703 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0145 | 0.2695 | 0.2763 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0467 | 0.9753 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0467 | 0.9753 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0467 | 0.9753 | 0.9753 |
Echinococcus granulosus | snurportin 1 | 0.0328 | 0.6703 | 0.6703 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.0178 | 0.0178 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0178 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.0178 | 0.0178 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0178 | 0.0178 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0467 | 0.9753 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0467 | 0.9753 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0051 | 0.0052 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0178 | 0.0183 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0178 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.6703 | 0.6703 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0467 | 0.9753 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.04 uM | Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 23291120 |
Inhibition (binding) | < 5 % | Inhibition of PI3K p110alpha/p85alpha (unknown origin) at 50 uM by ADP-Glo assay | ChEMBL. | 23291120 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23291120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.